000			04050cam a22003737i 4500
001			18660684
008			180207t2015 ja a b 001 0 eng d
010			_a2015944101
020			_a9784431555759 _qhardback : alk. paper _ceur119.99
020			_a4431555757 _qhardback : alk. paper
035			_a(OCoLC)ocn914163530
040			_aNLM _beng _cNLM _erda _dOHX _dYDXCP _dBTCTA _dGZO _dOCLCF _dDLC _aSFPAGOH
050	0	0	_akpm QP623 _b.L848 2015
245	0	0	_aLong noncoding RNAs : _bstructures and functions / _cRiki Kurokawa, editor.
264		1	_aTokyo ; _aNew York : _bSpringer, _c2015
264			_c©2015
300			_aviii, 257 pages : _billustrations (chiefly color) ; _c25 cm
336			_atext _2rdacontent
337			_aunmediated _2rdamedia
338			_avolume _2rdacarrier
504			_aIncludes bibliographical references and index.
505	0		_aPart I Bioinformatics and Other Methodologies for lncRNAs -- 1 Complexity of Mammalian Transcriptome Analyzed by RNA Deep Sequencing -- 2 Synthetic Strategies to Identify and Regulate Noncoding RNAs -- Part II Atomic and Molecular Structures of lncRNAs -- 3 Structure and Interaction with Protein of Noncoding RNA: A Case for an RNA Aptamer Against Prion Protein -- 4 Characterization of G-quadruplex DNA- and RNA-binding Protein -- Part III Molecular Functions of lncRNAs -- 5 Initiation of Transcription Generates Divergence of Long Noncoding RNAs -- 6 Beneath the Veil of Biological Complexity There Lies Long Noncoding RNA: Diverse Utilization of lncRNA in Yeast Genomes -- 7 Long Noncoding RNAs as Structural and Functional Components of Nuclear Bodies -- Part IV Biological Actions of lncRNAs -- 8 Long Noncoding RNA in Epigenetic Gene Regulation -- 9 Mechanisms of Long Noncoding Xist RNA-mediated Chromosome-wide Gene Silencing in X-chromosome Inactivation -- Part V Potential Outcomes for Clinical Medicine -- 10 Regulation of pRB and p53 Pathways by Long Noncoding RNAs, ANRIL, lincRNA-p21, lincRNA-RoR and PANDA -- 11 The Role of Androgen-regulated Long Noncoding RNAs in Prostate Cancer -- 12 Macrophage Activation as a Model System for Understanding Enhancer Transcription and eRNA Function -- 13 Long Noncoding RNA Functions as a Regulator for Steroid Hormone Receptors Related Breast and Prostate Cancers -- BM Index.
520			_aThis book presents a common principle of actions of long noncoding RNAs (lncRNAs) from points of view at the atomic, molecular, and cellular levels. At the atomic level, chemical studies of ribonucleic acids explain the chemical behavior of lncRNAs. Structural biological analysis of lncRNAs and its binding proteins also reveal the precise mechanisms of their actions. Molecular biological approaches lead to insights into molecular mechanisms of these lncRNA actions. At the cellular or individual level of analysis, we grasp the biology and medicine of lncRNAs. These three layers of approaches are thoroughly new and produce novel insights into functions of lncRNAs in living cells. The book consists of five parts: 1) Bioinformatics and other methodologies for lncRNAs, 2) Atomic and molecular structures of lncRNAs, 3) Molecular functions of lncRNAs, 4) Biological actions of lncRNAs, and 5) Potential outcomes for clinical medicine. These sections connect well and work synergistically. The book is for researchers whose specialty is RNA biology and chemistry and also for advanced students at the graduate and undergraduate levels. Readers can grasp the leading edge of lncRNA studies in a comprehensive manner and are inspired to pursue their own particular interests. -- _cSource other than Library of Congess.
650		0	_aNon-coding RNA.
650	1	2	_aRNA, Long Noncoding _xchemistry.
650	2	2	_aRNA, Long Noncoding _xphysiology.
700	1		_aKurokawa, Riki, _eeditor.
907			_a.b10063572 _b28-11-19 _c07-02-18
998			_am _b07-02-18 _cm _da _e- _feng _gja _h0
999			_c3948 _d3948